Oxlade-Chamberlain knows the significance of the meeting with group leaders Montenegro who are currently two points ahead of England after Friday's 1-0 win in Moldova.
He said: "It is the key game, definitely. It is good to win every game but, with them being top of the group, it is even more important.
"You can't look too far into it because you then start getting distracted, and it puts added pressure onto you.
"We know what we've got to do, it's a pressure game but they are all pressure games for us.
"It will be hostile but if you look around this squad, the players have experienced hostile environments before at club and international level.
"It is a different challenge for us to overcome but, at the end of the day, it's a game of football and what goes on inside the white lines isn't to do with who is outside of them.
"We will speak about tactics before the game. If we can match them mentally and physically and approach the game in a right way, we've got a good chance."