The Pole insists he won't be intimidated by the atmosphere at Elland Road.
"I played at Elland Road with Brentford and we got a draw, and I am hoping for a better result," he said.
"It is quite a loud ground, but I enjoy the atmosphere, it gives you a bit more motivation, keeps you focused.
"When you play games with no crowd, you can sometimes lose your concentration, so I enjoy the games at big stadiums with big crowds."
That made Manchester United the ideal place for Szczesny to be handed his Barclays Premier League debut a month ago.
"It was not really hard, I treat every game the same," the 20-year-old said of his baptism of fire.
"It does not matter whether it is at Old Trafford or on loan at Brentford with only 2,000 people there."