Arsenal boss Arsene Wenger is set to withdraw Jack Wilshere for their clash with Everton.
Wilshire was outstanding for victory at Europa League opponents Red Star Belgrade.
Wenger said: “It is impossible to come from a game of that intensity and play.
“Of course, I left 10 or 11 players at home. I decided to rotate at the start of the season and will continue to do so.
“Yes [it is a bit harsh on the team picked in Belgrade], but the time will come when the rotation can go another way."