Gunners captain Fabregas has been out since March 6 - missing the matches with Porto and Hull - due to a hamstring injury but is expected to pass a fitness test on Friday morning.
William Gallas has missed the last six games and is set to be out for at least two more matches - missing the Hammers contest and the match at Birmingham on March 27.
"Cesc and Tomas have a final test tomorrow morning," Wenger told Arsenal TV Online on Thursday.
"They should be available for Saturday.
"From the last game we don't lose anybody. So normally we should have Fabregas, Carlos Vela and Rosicky back. Plus of course we have Song coming back from suspension.
"However, William Gallas will not be available this week or at Birmingham. It is going on and on. It is a concern.