Wenger is frustrated that van Persie is out yet again - this time with flu. The Dutch striker only made his latest comeback from a muscle problem against Spurs in midweek.
Wenger, who yesterday picked up the Barclays Premier League Manager of the Month award for December, said: "For Robin, this season has been unbelievable. He has only played eight games.
"I am frustrated but it is part of my job, coping with these things."