The Gunners kick off their Champions League group campaign against Dynamo Kiev in Ukraine on Wednesday night in the first of three away games following the international break.
To earn their right to again compete with Europe's best, Wenger's squad faced a potentially tricky qualifying tie against Dutch outfit FC Twente - the first leg of which came before the start of the new domestic season.
It is a situation which the Arsenal manager feels has to be addressed.
"There is not much you can say, but the Premier League do not do a lot for us. The qualifiers are in a very bad position," he observed.
"Then the international friendly comes at a bad time for a team which plays in the qualifiers for the Champions League.
"But the main reproach I make - and I have asked this for a long, long time - is that the second [international] game is on the Tuesday.
"For example, Carlos Vela played on Wednesday night - but he did not finish until 4am on Thursday morning, because that was 9pm in Mexico.
"It means it is impossible to get that sort of player back for the next league game.
"You end up paying the players to go to the national team for two games and then you can't use them.
"You have a two-week break, but you can't even use them when they return."