The Belgium international has been out with an Achilles injury but started at the Emirates Stadium, playing 84 minutes before coming off with a "tight calf".
"He did very well but he had to come off for a calf problem," Wenger said. "I hope it is not too bad.
"He will be a bit short for Saturday. I do not know yet what has happened.
"We will have to test him tomorrow but it did not look too bad.
"He has been out for a long time and only had one training session yesterday with the team.
"I didn't expect a game of that intensity because it was a really tough game for a centre-back tonight as they put us under pressure in the second half."
He added: "I don't think it is a calf strain, I think it is just a tight calf because he has not played 90 minutes for three months.
"He wanted to come off. In fairness, I did not want to take him off because I thought it was stupid now with four minutes to go in case we concede a goal.
"He was adamant he could not go on so I hope it is not too bad."