Arsenal boss Arsene Wenger has named several youngsters in his Champions League squad.
Zak Ansah, Sead Hajrovic, Elton Monteiro, Chuba Akpom and James Shea could all see action against Olympiakos.
"Some players needed a rest because they were a bit on the fringe of injury, and some players are injured," explained Wenger before travelling to Greece.
"When I count the injured players I speak about Podolski and Walcott. We needed to rest Wilshere, 100 per cent, and Cazorla, Arteta and Mertesacker played many games recently. They have been rested."