Wenger's squad has been resurgent in recent times, winning nine of their last 11 fixtures in all competitions to get their campaign back on track. And the Frenchman wants them to hit the ground running when they travel to Norwich on November 19.
"It [the international break] is certainly not a joy for me but hopefully it is not a pain because I hope the players will come back in good spirits," Wenger told arsenal.com. "But it could be a pain if we lose some players through injury.
"I don't believe [it will upset our rhythm]. It's always a challenge to get the focus back quickly when players come from international games but let's hope we can sort that out."