Arsenal are a point behind the fifth-placed Toffees and Wenger urged against any complacency.
"They are always serious, Everton, because they can give anybody a game," said Wenger.
"I don't think any big team in the league goes to Everton and thinks it will be a walk out there. For us it's a vital game every year. They fight at the top of the league every year. They are one of the contenders for a Champions League spot as well.
"Everton have gone through a more difficult spell recently, but it will just be down to us and the quality of our performance."