Fabregas and Nasri's departures have coincided with the start of Arsenal's campaign but Wenger believes that the rest of his squad will rise above recent events to get the right result in Italy.
"There is always a concern [that players can be affected] but it is not an excuse," the manager told arsenal.com.
"You are always concerned about the consequences it can have on the team. It can have a positive consequence as well - if you are strong mentally it can increase the solidarity, knowing you have to fight more.
"That is ideally what you want from mentally strong players."