Cazorla expects the defending champs to remain strong under David Moyes.
"I do not think it influences too much," said Cazorla.
"The most radical change is at Manchester United because Ferguson has been there for so long.
"It will be a little difficult at the start for a new manager, but I don't think it influences too much in terms of being and advantage for other teams.
"There are great managers at those clubs and I am sure it will be just as difficult."