Andres Villas-Boas has left Tottenham "by mutual consent".
Spurs said the decision was "by mutual consent" although after Villas-Boas said he would fight on following Sunday's loss, the move will be widely seen as a sacking.
A statement from the club on Monday morning read: "The club can announce that agreement has been reached with head coach, Andre Villas-Boas, for the termination of his services.
"The decision was by mutual consent and in the interests of all parties.
"We wish Andre well for the future.
"We shall make a further announcement in due course."
The Portuguese leaves with the White Hart Lane club seventh in the Premier League table, eight points off top spot and five outside the top four.