Anelka saw his penalty saved by Tim Howard while Cole blazed over as the defending champions lost 4-3 on spot-kicks after the game ended all square following extra-time.
"Nicolas Anelka tried a lot of times to shoot and scored. Obviously penalties are a lottery, sometimes you win and sometimes you lose."
But the Italian insists his players must bounce back.
He said: "We're not in an easy moment.
"We have to play some very important games, but sometimes it is good to play tough games as you have more focus.
"We're not afraid to play against Copenhagen. We will try everything to recover."