The 19-year old attacker has not yet played this season because of a knee injury but trained during the week and could be set for a recall when the Red Bulls head to Los Angeles to take on LA Galaxy.
The potential return of Agudelo comes at a good time for New York as star striker Thierry Henry is set to miss about four weeks with a hamstring injury.
Red Bulls head coach Hans Backe suggests Agudelo, who scored six goals form 12 MLS starts last season, should be right to play some part at The Home Depot Center on Saturday.
"Twenty minutes, I would guess. 20-25 minutes," he said.