Ledesma has been forced to make way for Lucas Biglia.
"It is strange not seeing him in the starting XI," agent Vincenzo D'Ippolito told Radio Manà Manà.
"He is a silent leader who deserves to play, even if he is accepting the bench for the good of Lazio. He has always given everything for this jersey, providing a fundamental contribution to the team even in the most difficult moments.
"It is right that Vladimir Petkovic try Biglia now, but the two have different characteristics and I don't think they are incompatible. I don't see why they couldn't play together."
For the big stories and the banter follow us on Twitter: @tribalfootball